Be an advocate for yourself, your patients, and your community by learning about this complex disease.

Education Is Key.

Are you a patient just learning about your antibodies? Start here for an introduction to what is happening in your body.

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Provider Resources.

Are you a provider looking for the most current, evidence-based guidelines for the management of alloimmunized pregnancies?

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We have a growing resource library.

Alternatives to Natural Conception

Alternatives to Natural Conception

A diagnosis of maternal alloimmunization does not have to determine your family size. In addition to adoption and foster care, there are many alternatives to natural conception. For couples who prefer to have a natural pregnancy, see our pregnancy tour for proactive treatment options such as IVIG and plasmapheresis. Couples may also be able to participate in a clinical trial. There are four main alternatives to natural conception: sperm donation, surrogacy, in vitro fertilization with preimplantation genetic diagnosis (IVF with PGD), and embryo adoption. It must be clearly stated that in order to avoid HDFN due to maternal alloimmunization, all donor material must be antigen negative. There is no risk of HDFN if the fetus is antigen negative.

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Common Alloimmunization Misconceptions

Common Alloimmunization Misconceptions

Rh Disease has been eradicated. False!

Rh disease has not been eradicated. Since the invention of Rh Immune Globulin (RhoGAM), sensitization rates for anti-D alloimmunization have plummeted, however, anti-D alloimmunization still occurs. For some women, Rhogam simply doesn’t work. Others are not given a high enough dose, or are not treated at the appropriate time. Since the number of women developing anti-D has decreased dramatically, alloimmunization to other antigens has become more common. Anti-Kell, anti-E, and anti-c are 3 clinically significant antibodies that are now most commonly found among pregnant women.

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History of Alloimmunization and Treatment Options

History of Alloimmunization and Treatment Options

A history of alloimmunization from the 1600s to present. Discover the advances in testing, treatment, and outcomes for patients with Hemolytic Disease of the Fetus and Newborn (HDFN) over the past 400 years.

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Current Research and Clinical Trials.

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We Are Here To Help.

Whether it’s a question, a need for resources, prayer/emotional support, or something else, we love to hear from you. Contact us via email or social media.

Mission Statement

Our mission is to prevent any harm, stillbirth or infant death caused by alloimmunization and HDFN. We are dedicated to providing patient advocacy, support and education while promoting research and improving healthcare practices for the condition.