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What is Alloimmunization and how does it cause HDFN?

Maternal alloimmunization occurs when a woman makes red blood cell antibodies as a result of foreign blood mixing. These antibodies can cross the placenta and attack the unborn child, a disease called hemolytic disease of the fetus and newborn (HDFN). HDFN can have devastating consequences including anemia, hyperbilirubinemia, and death. With close monitoring and timely treatment, babies with HDFN have a very high survival rate. Unfortunately, due to the rarity of alloimmunization and the variation in care practices around the world, well-managed pregnancies and ideal infant outcomes are not universal - but they can be!

The Allo Hope Foundation was founded to provide educational materials, family and provider support, and to promote research related to alloimmunization and HDFN.

About Us

Be an advocate for yourself, your patients, and your community by learning about this complex disease.

Education Is Key.

Are you a patient just learning about your antibodies? Start here for an introduction to what is happening in your body.

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Provider Resources.

Are you a provider looking for the most current, evidence-based guidelines for the management of alloimmunized pregnancies?

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Ways You Can Help

Current Research and Clinical Trials

Understand The Terminology

Test Your Allo Knowledge

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We have a growing resource library.

Prenatal Decision Tree

The Prenatal Decision Tree can be used as a step by step guide through the proper course of prenatal care for alloimmunized patients according to current medical literature. If your care plan differs from this, discuss it with your physicians and seek a second opinion if needed. For additional references and a more in-depth explanation of the information in this tree, please see our Providers page.

History of Alloimmunization and Treatment Options

A history of alloimmunization from the 1600s to present. Discover the advances in testing, treatment, and outcomes for patients with Hemolytic Disease of the Fetus and Newborn (HDFN) over the past 400 years.

Necessary and Optional Laboratory Assessments for the Mother, Father, and Fetus

There are a variety of laboratory tests that should be offered to the alloimmunized patient. It is important to test both the mother and the father during an alloimmunized pregnancy. By testing both parents, it is possible to get a more accurate view of the risk of HDFN.

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Allo Stories

Journey with our families as they go through pregnancy dealing with alloimmunization and HDFN.

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Disclaimer: The purpose of this website is to provide general education, access to resources, and relevant literature. This website does not provide specific medical advice or recommendations for individual patients and is not a substitute for speaking with qualified healthcare professionals. The Allo Hope Foundation strongly recommends that care and treatment related to alloimmunization and HDFN be made in consultation with your physicians who are familiar with your individual health situation.

The Allo Hope Foundation - Protecting babies, supporting families.

We Are Here To Help.

Whether it’s a question, a need for resources, prayer/emotional support, or something else, we love to hear from you. Contact us via email or social media.

Mission Statement

Our mission is to prevent any harm, stillbirth or infant death caused by alloimmunization and HDFN. We are dedicated to providing patient advocacy, support and education while promoting research and improving healthcare practices for the condition.