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What is Alloimmunization and how does it cause HDFN?

Maternal alloimmunization occurs when a woman makes red blood cell antibodies as a result of foreign blood mixing. These antibodies can cross the placenta and attack the unborn child, a disease called hemolytic disease of the fetus and newborn (HDFN). HDFN can have devastating consequences including anemia, hyperbilirubinemia, and death. With close monitoring and timely treatment, babies with HDFN have a very high survival rate. Unfortunately, due to the rarity of alloimmunization and the variation in care practices around the world, well-managed pregnancies and ideal infant outcomes are not universal - but they can be!

The Allo Hope Foundation was founded to provide educational materials, family and provider support, and to promote research related to alloimmunization and HDFN.

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Be an advocate for yourself, your patients, and your community by learning about this complex disease.

Education Is Key.

Are you a patient just learning about your antibodies? Start here for an introduction to what is happening in your body.

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Provider Resources.

Are you a provider looking for the most current, evidence-based guidelines for the management of alloimmunized pregnancies?

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Current Research and Clinical Trials

Understand the Terminology

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Cell-Free Fetal DNA (cffDNA) Testing

cffDNA testing is the safest option for determining if a fetus is antigen positive and at risk for HDFN. Women from around the world can have their blood drawn and shipped off to have the test done. Here is more information about cffDNA testing and the necessary forms for testing.

Necessary Laboratory Assessments for Infants Exposed to Maternal Alloantibodies

There are a variety of laboratory tests that are necessary for infants born to alloimmunized mothers. It is important to confirm or rule out the presence of HDFN. Infants who are affected by HDFN require weekly follow up lab assessment for hemoglobin/hematocrit until ~12 weeks of age or until weekly counts are rising for 2-3 consecutive weeks.

Necessary and Optional Laboratory Assessments for the Mother, Father, and Fetus

There are a variety of laboratory tests that should be offered to the alloimmunized patient. It is important to test both the mother and the father during an alloimmunized pregnancy. By testing both parents, it is possible to get a more accurate view of the risk of HDFN.

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Allo Stories

Journey with our families as they go through pregnancy dealing with alloimmunization and HDFN.

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Disclaimer: The purpose of this website is to provide general education, access to resources, and relevant literature. This website does not provide specific medical advice or recommendations for individual patients and is not a substitute for speaking with qualified healthcare professionals. The Allo Hope Foundation strongly recommends that care and treatment related to alloimmunization and HDFN be made in consultation with your physicians who are familiar with your individual health situation.

The Allo Hope Foundation - Protecting babies, supporting families.

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Whether it’s a question, a need for resources, prayer/emotional support, or something else, we love to hear from you. Contact us via email or social media.

Mission Statement

Our mission is to prevent any harm, stillbirth or infant death caused by alloimmunization and HDFN. We are dedicated to providing patient advocacy, support and education while promoting research and improving healthcare practices for the condition.