Research, clinical guidance, and educational resources developed by or with
contributors from the Allo Hope Foundation to improve outcomes and care.
Featured clinical guideline
A Clinical Practice Guideline for the Management of Pregnancy
Alloimmunized to Red Blood Cell Antigens
Moise KJ, Markham KB, Spinella PC, Sherwood MR, Robinson KA, Wilson LM,
Malone J, Espinoza J, Dizon-Townson D, Mercer L, Miller R, Pereira L,
Sciscione A, Shamshirsaz AA, Shanahan K, Snowise S, Trevett T, González
Vélez JM, Weathersby B. JAMA Network Open.
2025;8(11):e2544649.
Evidence-based recommendations for the management of alloimmunized
pregnancies. For the complete recommendations, practice points, and
rationales, open the supplemental content and review Table 4.
Read the guideline
Understanding Patient Perspectives and Experiences in Severe Hemolytic
Disease of the Fetus and Newborn: Insights From Qualitative Interviews
Barlassina A, Sherwood M, Mohan D, Boeri M, Janssen E, Krumme A, Bozzi
L. American Journal of Perinatology Reports.
2026;16(03):e171–e178.
Interviews with 28 women who experienced severe HDFN examining care
quality, effects on daily life, and psychosocial burdens.
RhD-Positive Transfusion in Females of Childbearing Potential in
Hemorrhagic Shock: Risk, Reality, and Policy
Murphy TO, Spinella PC, Young PP, Emery SP, Kulaste R, Leeper CM,
Hopkins CK, Sherwood MR, Müller DE, Horvath S, Pink J.
Prehospital Emergency Care. Published online July 11,
2026:1–7.
A multidisciplinary discussion of clinical decision-making and the
implications of RhD-positive transfusion for females of childbearing
potential during international blood shortages.
The THOR Network Best Practices for Females of Childbearing Potential
With Life-Threatening Hemorrhage
Levy MJ, OByrne H, Bank EA, Cannon JW, Cap AP, Glassberg E, Holcomb JB,
Jenkins DH, Leeper C, Sherwood MR, Ward KR, Yazer MH, Spinella PC.
Transfusion. 2026;66(S1):S5–S14.
Practical guidance for emergency medical services and hospitals caring
for females of childbearing potential with life-threatening bleeding.
A Critical Moment: Standardizing Red Blood Cell Antibody Reporting to
Reduce Hemolytic Disease of the Fetus and Newborn Risk
Sherwood M, Weathersby B, Moise KJ Jr, González Vélez JM, Shanahan K,
Shmookler A, Delaney M. Transfusion.
2026;66(3):614–625.
A commentary describing the risks of inconsistent antibody reporting
and proposing standardized, guidelines-based feedback after a positive
antibody screen, illustrated by patient cases from AHF.
Hemolytic Disease of the Fetus and Newborn: A Mixed-Methods Preference
Study
Mohan D, Barlassina A, Boeri M, Sherwood M, Janssen EM, Krumme A, Bozzi
LM. Value in Health. 2025;28(6):S311–S312.
A mixed-methods study examining how women with severe HDFN experience
treatment decisions and weigh potential benefits and burdens.
Alloimmunization in Pregnancy: Patient-Reported Quality of Care, Mental
Health Effects, and Impact Upon Daily Life
Sherwood MR, Weathersby BM, Granger ME, Shanahan KA, Markham KB.
American Journal of Perinatology Reports.
2025;15(03):e146–e153.
A survey of 127 mothers examining mental health, quality of care, and
effects on daily life, including differences between severe and
non-severe HDFN.
Patient-Reported Disease Presentation, Interventions, and Outcomes in
U.S. Pregnancies Affected by Alloimmunization
Sherwood MR, Weathersby BM, Granger Howard ME, Markham KB.
Children. 2025;12(7):822.
A study of 200 pregnancies examining antibody titers, antibody type,
treatment, and outcomes, including fetal deaths.
Development of Evidence-Based Guidelines for Emergency Resuscitation
of Females of Childbearing Potential
Sherwood MR, Andrews J, Bahr TM, Josephson CD, Leeper CM, Moise KJ,
Yazer MH, Polk TM, Spinella PC. Vox Sanguinis.
2025;120(S1):42.
A precursor to the emergency transfusion practice guideline presenting
the systematic-review and Delphi-consensus methodology.
Conference abstract
A Review of Attitudes to Urgent RhD-Positive Transfusions in Female
Patients and the Risk for HDFN
Yazer MH, Spinella PC, Holcomb JB, Horvath S, Sherwood MR, Emery SP,
Leonard JC, Leeper CM. Transfusion.
2024;64(9):1784–1790.
A review of patient and clinician attitudes toward using RhD-positive
blood in female patients when RhD-negative products are unavailable.
Hemolytic Disease of the Fetus and Newborn
Sherwood MR, Moise KJ. National Organization for Rare Disorders. May 6,
2024.
An accessible overview of HDFN symptoms, causes, diagnosis, and
treatment for patients, families, and readers new to the disease.
