Resource Hub
For patients, families, and providers managing red blood cell alloimmunization, also referred to as isoimmunization, Rh incompatibility, Rh disease, hemolytic disease of the fetus and newborn, HDFN, or HDN. Many newly diagnosed families first learn about alloimmunization after a positive antibody screen in pregnancy.
Red blood cell antibodies can include anti-D, anti-c, anti-C, anti-K / Kell, anti-E, anti-e, and other clinically significant antibodies.
Common search terms and related diagnoses:
Just Diagnosed
If you’re not sure where to begin, start here. These resources explain the diagnosis, key terms, common questions, and what severe disease may involve.
Just Diagnosed
A starting point for families who have recently learned about alloimmunization, HDFN, or a positive antibody screen.
Frequently Asked Questions
Answers to common patient and family questions about antibodies, monitoring, pregnancy care, and newborn care.
Terms & Definitions
A plain-language glossary of common HDFN, alloimmunization, pregnancy, and newborn care terms.
Special Considerations for Severe Disease
A printable resource for families facing a higher-risk or more complex alloimmunized pregnancy.
Prenatal Resources
Resources for safe pregnancy management after a positive antibody screen.
Provider Pocket Guide
A basic overview of HDFN care including key management considerations.
Excellent Prenatal Care Practices *
A checklist-style resource outlining recommended prenatal care practices.
Letter to Providers *
A printable letter patients can bring to an OB, MFM, or care team to help advocate for appropriate monitoring and management.
Calculators & Tools
Tools to help calculate MoM values from MCA Doppler scans, estimated fetal weight, and survival rates.
Prenatal Booklet
In-depth patient education about alloimmunization, HDFN, monitoring, treatment options, and what to expect during pregnancy.
Prenatal Flowchart *
A visual decision-tree style resource to help families understand the pathway of prenatal monitoring and escalation of care.
Guidelines Implementation Checklist *
A checklist to support implementation of evidence-informed care practices for alloimmunized pregnancies.
Neonatal Resources
Resources for newborn care after HDFN, including jaundice, anemia, bilirubin monitoring, transfusion considerations, and follow-up after discharge.
Excellent Neonatal Care Practices *
A checklist-style resource outlining recommended neonatal care practices.
Newborn Booklet
In-depth patient education about what to expect after birth.
Calculators & Tools
Tools to help calculate bilirubin treatment thresholds, lab values for HDFN, and weight for age percentile.
HDFN Health Record *
A printable record families can use to track their babies medical course from pregnancy through the neonatal period.
Clinician Resources
Resources for OBs, MFMs, pediatricians, neonatologists, transfusion medicine teams, blood banks, and other clinicians caring for alloimmunized pregnancies and newborns with HDFN.
Provider Pocket Guide
Letter to Providers
Excellent Prenatal Care Practices
Excellent Neonatal Care Practices
Prenatal Flowchart
Provider Primer
A clinician-oriented primer on HDFN and alloimmunization.
Transfusion Medicine
Information related to transfusion medicine, blood bank considerations, and HDFN care.
