Just Diagnosed
A starting point for families who have recently learned about alloimmunization, HDFN, or a positive antibody screen.
Diagnosed with Antibodies in Pregnancy? Start Here
If you’ve been told you have antibodies or a positive antibody screen, you are in the right place! With proper care and the right doctor, most families have safe alloimmunized pregnancies and healthy babies.
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Allo Hope Foundation
Resource Library
For patients, families, and providers managing red blood cell alloimmunization, also referred to as isoimmunization, Rh incompatibility, Rh disease, hemolytic disease of the fetus and newborn, HDFN, or HDN. Many newly diagnosed families first learn about alloimmunization after a positive antibody screen in pregnancy.
Red blood cell antibodies can include anti-D, anti-c, anti-C, anti-K / Kell, anti-E, anti-e, and other clinically significant antibodies.
Looking for something to print?
The starred resources below are designed to be
printed and shared with your OB, MFM, pediatrician,
neonatologist, transfusion medicine team,
or hospital care team.
Common search terms and related diagnoses:
Just Diagnosed
If you're not sure where to begin, start here. These resources explain the diagnosis, key terms, common questions, and the history of HDFN.
Frequently Asked Questions
Answers to common patient and family questions about antibodies, monitoring, pregnancy care, and newborn care.
Terms & Definitions
A plain-language glossary of common HDFN, alloimmunization, pregnancy, and newborn care terms.
History of HDFN
Explore the history of hemolytic disease of the fetus and newborn and how advances in prevention and treatment have shaped care today.
Prenatal Resources
Resources for safe pregnancy management after a positive antibody screen.
Find a Doctor
Find physicians with experience caring for alloimmunized pregnancies and families affected by HDFN.
Pregnancy Week by Week
Learn what monitoring, decisions, and care may involve at different stages of an alloimmunized pregnancy.
Interventions During Pregnancy
Learn about interventions that may be used to manage fetal anemia and other complications during pregnancy.
Rh-Negative Pregnancy
Understand Rh incompatibility, Rh immune globulin (RhIG), and the prevention of anti-D alloimmunization.
Special Considerations for Severe Disease
A printable resource for families facing a higher-risk or more complex alloimmunized pregnancy.
Alternatives to Natural Conception
Explore family-building options and considerations for future pregnancies affected by alloimmunization.
HDFN Health Record
A resource for tracking important details about pregnancy, treatment, and newborn care.
Provider Pocket Guide
A basic overview of HDFN care including key management considerations.
Excellent Prenatal Care Practices *
A checklist-style resource outlining recommended prenatal care practices.
Letter to Providers *
A printable letter patients can bring to an OB, MFM, or care team to help advocate for appropriate monitoring and management.
Calculators & Tools
Tools to help calculate MoM values from MCA Doppler scans, estimated fetal weight, and survival rates.
Prenatal Booklet
In-depth patient education about alloimmunization, HDFN, monitoring, treatment options, and what to expect during pregnancy.
Prenatal Flowchart *
A visual decision-tree resource to help families understand the pathway of prenatal monitoring and escalation of care.
Guidelines Implementation Checklist *
A checklist to support implementation of evidence-informed care practices for alloimmunized pregnancies.
Neonatal Resources
Resources for newborn care after HDFN, including jaundice, anemia, bilirubin monitoring, transfusion considerations, and follow-up after discharge.
Excellent Neonatal Care Practices *
A checklist-style resource outlining recommended neonatal care practices.
Newborn Booklet
In-depth patient education about what to expect after birth.
Calculators & Tools
Tools to help calculate bilirubin treatment thresholds, lab values for HDFN, and weight-for-age percentiles.
HDFN and Iron
Learn about iron levels and important considerations for iron supplementation in infants affected by HDFN.
HDFN Health Record *
A printable record families can use to track their baby's medical course from pregnancy through the neonatal period.
Explore HDFN Topics in Depth
Looking for more detailed information? Explore our collection of educational articles and additional reading on specific aspects of alloimmunization and HDFN.
Additional Reading by Topic
Explore specific HDFN topics, including red blood cell antibodies, prenatal testing, fetal monitoring, transfusions, and newborn care, with links to supporting literature.
Explore Topics →Clinician Resources
Resources for OBs, MFMs, pediatricians, neonatologists, transfusion medicine teams, blood banks, and other clinicians caring for alloimmunized pregnancies and newborns with HDFN.
Provider Pocket Guide
A concise overview of alloimmunization and HDFN management considerations.
Letter to Providers
A printable letter highlighting important management considerations for alloimmunized pregnancies.
Excellent Prenatal Care Practices
A checklist of recommended prenatal management and monitoring practices.
Excellent Neonatal Care Practices
Recommended practices for neonatal monitoring, treatment, and follow-up.
Prenatal Flowchart
A clinical decision tree for monitoring and managing alloimmunized pregnancies.
Provider Primer
A clinician-oriented primer on HDFN and alloimmunization.
Transfusion Medicine
Information related to transfusion medicine, blood bank considerations, and HDFN care.
Guidelines Implementation Checklist
A point-of-care checklist supporting implementation of the HDFN clinical practice guidelines.
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